Cyclodextrins Micronization by Supercritical Assisted Atomization
نویسندگان
چکیده
Supercritical Assisted Atomization (SAA) has been used to micronize α-cyclodextrin (α-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD). The effect of some process parameters such as precipitation temperature and solute concentration in the liquid solution has been studied to evaluate their influence on morphology and size of precipitated particles. Cyclodextrins micronization has been obtained with sharp particle size distributions. Welldefined spherical microparticles of α-CD and HP-β-CD have been produced, ranging between 0.1 and 30 μm and between 0.5 and 20 μm, respectively. X-ray and DSC analyses have been also performed to investigate cyclodextrins modifications after SAA processing: amorphous particles have been obtained in both cases, whereas raw αCD was crystalline and raw HP-β-CD was amorphous.
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